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Key Points Of This Chapter   Fluid bed coating is more challenging than fluid bed granulation and drying.   Traditional overhead sprays are easiest to scale. However, this technology is not suitable for functionally coated dosage forms. The amplification of the spray rate is usually calculated based on the increase in the amount of fluidizing […]

Key Points Of This Chapter   Statistical design of experiments is helpful for process scale-up, but for fluidized beds it is not possible to simply rely on process variables for scale-up, but rather to identify and account for all key sources of variability, to manage the variability through the process, and to predict Product quality

Key Points Of This Chapter   For process control, we must first have a deep understanding of the purpose of the product process, including the attributes of raw materials and auxiliary materials, processing unit attributes, and product quality attributes, so as to formulate clear and effective strategies, and finally choose the appropriate method for implementation.

Chapter 9 Other Processes And Applications Of Fluidized Bed   01 Introduction   Over the past 50 years, fluidized bed processes have evolved from simple drying units to granulation, coating and various other application technologies. Notable among them are: the use of low-melting point waxes and polymers for granulation in fluidized beds; the use of

Key Points Of This Chapter   In addition to the traditional understanding of granulation, top spraying can also be used for coating some products. However, this kind of coating, unlike the conventionally understood bottom spray coating, cannot fully achieve functional coating, but plays a certain role. barrier, and cannot achieve precise coating. The most suitable

Key Points Of This Chapter   The basic principle of drying, the advantages of fluidized bed drying compared to box drying: high efficiency, large load capacity, less manual intervention, and short time.   Fluidized bed drying includes short preheating stage, constant speed stage and speed reduction stage. In order to maintain good drying effect and

Key Points Of This Chapter   The granulation process is actually about finding the balance point between spray and evaporation, as well as the relationship between particle growth and fluidization parameters. This seemingly simple process is not simple in actual application because, as mentioned before, pharmaceutical fluidized bed applications are still in a “blind box”

Key Points Of This Chapter   The selection of the process is based on the characteristics of the API and the properties of the excipients, which must be comprehensively considered through reasonable evaluation methods. When there are many influencing factors, in order to find CQAs more quickly and effectively, it is necessary to conduct DoE

Key Points Of This Chapter   Only at the beginning of this chapter do we really get into the interpretation of fluidized bed hardware. The design of hardware is based on process requirements. Everyone must firmly believe in this. No piece of equipment can satisfy all types of certain processes. There must be an optimal

Film coating technology is to use a certain process to coat a coating material on the surface of the drug, which can play various functions such as beautification, protection and control of the drug effect as expected. This technology can overcome the shortcomings of many medicines, such as bitter taste, rough surface of the tablet