Search Results for: Granulation Line

Key Points Of This Chapter   The basic principle of drying, the advantages of fluidized bed drying compared to box drying: high efficiency, large load capacity, less manual intervention, and short time.   Fluidized bed drying includes short preheating stage, constant speed stage and speed reduction stage. In order to maintain good drying effect and […]

Key Points Of This Chapter   The granulation process is actually about finding the balance point between spray and evaporation, as well as the relationship between particle growth and fluidization parameters. This seemingly simple process is not simple in actual application because, as mentioned before, pharmaceutical fluidized bed applications are still in a “blind box”

Key Points Of This Chapter   The selection of the process is based on the characteristics of the API and the properties of the excipients, which must be comprehensively considered through reasonable evaluation methods. When there are many influencing factors, in order to find CQAs more quickly and effectively, it is necessary to conduct DoE

Key Points Of This Chapter   Only at the beginning of this chapter do we really get into the interpretation of fluidized bed hardware. The design of hardware is based on process requirements. Everyone must firmly believe in this. No piece of equipment can satisfy all types of certain processes. There must be an optimal

Film coating technology is to use a certain process to coat a coating material on the surface of the drug, which can play various functions such as beautification, protection and control of the drug effect as expected. This technology can overcome the shortcomings of many medicines, such as bitter taste, rough surface of the tablet

Due to the obvious advantages of direct powder compression, such as relatively simple process, no need for granulation and drying, fast product disintegration or dissolution, and stable product quality, about 40% of tablet varieties abroad have been produced by this process .   1 Application   ① Used for drugs that are easy to change

In recent years, the safety, stability and functionality of pharmaceutical excipients for oral solid dosage forms have received unprecedented attention. No matter the time, price is always our concern. But the most important thing besides considering the price factor is to ensure the quality of pharmaceutical excipients.   Therefore, taking lactose, cellulose derivatives, phosphate, and

Part 1 Introduction   With the development of science and technology, the intelligent manufacturing model is becoming a new hotspot and a new wind vane for technological competition and industrial protection in manufacturing. All walks of life in the world have carried out large-scale research, testing and exploration on intelligent manufacturing technology. Its production efficiency,

Changes in drug production sites may be related to changes in drug prescriptions, suppliers of raw and excipient materials, production processes, process parameters and batches, and other registration management matters, which is the most complicated of all change situations. This article discusses the technical risk considerations for the production site change of oral solid preparations

A generic drug is a drug that is consistent with the original drug (reference drug, RLD) in terms of dosage form, strength, route of administration, quality, curative effect, and use. Generics play a key role in the health care system, accounting for more than 50% of all prescriptions. Generic drugs are approved on the basis