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Key Points Of This Chapter   Lists 11 common problems in the granulation process: poor particle size distribution; formation of lumps or larger particles after the process; uneven distribution of poorly soluble API (active pharmaceutical ingredients); reduced API content; poor process air temperature control at low process air volume settings; bed stall; low yield; filter

Key Points Of This Chapter   The fluidized bed granulation and coating processes both involve the loading and unloading of materials. Since the core components and principles used in granulation and coating are different, in the process of loading and unloading, in addition to the most traditional In addition to manual operation, semi-automatic or automatic

Key Points Of This Chapter   Fluid bed coating is more challenging than fluid bed granulation and drying.   Traditional overhead sprays are easiest to scale. However, this technology is not suitable for functionally coated dosage forms. The amplification of the spray rate is usually calculated based on the increase in the amount of fluidizing

Key Points Of This Chapter   Only at the beginning of this chapter do we really get into the interpretation of fluidized bed hardware. The design of hardware is based on process requirements. Everyone must firmly believe in this. No piece of equipment can satisfy all types of certain processes. There must be an optimal

This article introduces several sterilization methods for sterile medicines: moist heat sterilization, dry heat sterilization, radiation sterilization, ethylene oxide sterilization and sterilization filtration, and studies the sterilization principles and effects of various sterilization methods. Factors, advantages and disadvantages, and products suitable for sterilization, etc., and through the sterilization method of solution dosage form products and

The sterility test of microspheres for injection should focus on both “outside sterility” and “inside sterility”, and the difficulty of detection is “inside sterility”, that is, the sterility test inside the microsphere. On the basis of investigating the production process of microspheres for injection, this study selected representative varieties, simulated the dissolution process of microspheres

Under the conditions of modern society, people begin to pay attention to the production and preparation process of medicines. In order to ensure the stability of drugs, relevant professionals have begun to develop important technologies for processing drugs, including freeze-drying technology. At present, most pharmaceutical companies use comprehensive drying technology, but there are still many

Combined with the production characteristics and design points of the chemical raw material medicine workshop, the overall layout, plane layout and steel platform layout of the chemical raw material medicine workshop are analyzed, and the problems that need attention in the design of the chemical raw material medicine workshop are summarized.   Part 1 Production