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With the deepening of drug research and development, the proportion of insoluble drugs in drug research and development is constantly increasing, and the problem of crystal form is becoming more and more prominent. Different crystal forms of drugs may affect their dissolution and release in vivo, which may affect the clinical efficacy and safety of […]

In the establishment of a generic drug project, in addition to the clinical, market, technical and registration strategy evaluation of the generic drug, there is another core template — patent evaluation, which is also a topic of great concern to everyone. For example, which patents are involved in generic drugs, how to ensure that the

Manufacturing offers many tantalizing opportunities for the future of biopharmaceuticals, from greater efficiencies to lower costs to improved process scalability. Many exciting new technologies are being investigated for upstream production and downstream purification of biopharmaceuticals in a continuous format. Although no commercialized biopharmaceuticals are currently in a fully continuous process and many technical challenges remain,

As the pharmaceutical market expands to new formats, manufacturers must manage multiple complex product pipelines faster than ever. But higher demand is straining capacity at biopharma companies. Therefore, innovative solutions are required to deliver and operate agile, flexible and integrated factories to seamlessly support new models from development to commercialization.   For greenfield plants using

After the drug preparation is administered, under the condition of the physiological medium in the human body, the preparation disintegrates into many small particles, the particles depolymerize, and the drug dissolves. The dissolved drug penetrates into the epithelial cells of the small intestine and is then absorbed into the blood circulation. Finally, it reaches the

Part 1 worst Condition   Theoretically, the different equipment involved in each variety should have its own cleaning operation procedures confirmed. However, in the practice of drug production, it is impossible and unnecessary for enterprises to spend manpower, material resources, and financial resources to confirm all the equipment involved one by one. This requires enterprises

There is a growing demand for biologics owing to clinical success, favorable safety data, and the ability of biologics to target the underlying causes of disease. Advances in proteins, peptides, nucleic acids, vaccines, and monoclonal antibodies (mAbs) have enabled rapid development of biopharmaceuticals, especially in recent years. According to an article in Molecules, 25 percent

Aceclofenac is a new type of powerful antipyretic, analgesic and anti-arthritic drug—in order to make aceclofenac into dispersible tablets more efficiently, the preparation process of aceclofenac dispersible tablets was carried out in this paper. Research. Based on the orthogonal test L9(3)4, the dosage of its main functional excipients was selected, and the preparation process of

Pharmaceutical emulsions are immiscible liquid disperse systems in which the dispersed phase is made of tiny globules of a liquid scattered across a vehicle. The dispersion medium is referred to as the continuous or external phase in emulsion nomenclature, whereas the dispersed phase is the discontinuous or internal phase.   Although it can be as

 Pharmaceutical Powders Powders are solid dosage forms made from dry crystals and appropriate excipients through comminution and blending. Drugs can be administered orally or locally. Manufacturing powders is simple by mixing of drug powders with excipients. There are specific regulations on particle size of powders according to the administrative route.If not otherwise specified,oral powders should