Search Results for: Powder Line

Key Points Of This Chapter   This chapter focuses on the potential risks in the use of fluidized beds, and mainly explains some solutions from the perspective of explosion prevention and cross contamination prevention.   According to the characteristics of different raw materials and auxiliary materials, when designing a fluidized bed process, risk assessment should

Key Points Of This Chapter   Lists 11 common problems in the granulation process: poor particle size distribution; formation of lumps or larger particles after the process; uneven distribution of poorly soluble API (active pharmaceutical ingredients); reduced API content; poor process air temperature control at low process air volume settings; bed stall; low yield; filter

Key Points Of This Chapter   Fluid bed coating is more challenging than fluid bed granulation and drying.   Traditional overhead sprays are easiest to scale. However, this technology is not suitable for functionally coated dosage forms. The amplification of the spray rate is usually calculated based on the increase in the amount of fluidizing

Key Points Of This Chapter   Statistical design of experiments is helpful for process scale-up, but for fluidized beds it is not possible to simply rely on process variables for scale-up, but rather to identify and account for all key sources of variability, to manage the variability through the process, and to predict Product quality

Key Points Of This Chapter   For process control, we must first have a deep understanding of the purpose of the product process, including the attributes of raw materials and auxiliary materials, processing unit attributes, and product quality attributes, so as to formulate clear and effective strategies, and finally choose the appropriate method for implementation.

Chapter 9 Other Processes And Applications Of Fluidized Bed   01 Introduction   Over the past 50 years, fluidized bed processes have evolved from simple drying units to granulation, coating and various other application technologies. Notable among them are: the use of low-melting point waxes and polymers for granulation in fluidized beds; the use of

Key Points Of This Chapter   Multi-unit pellet systems (MUPS) have multiple therapeutic and technical advantages compared with single-dose large doses. They are evenly distributed in the gastrointestinal tract and have fewer adverse reactions; they can also reduce the risk of dose dumping and have stackable bioavailability.   The use of fluidized bed to prepare

Key Points Of This Chapter   In addition to the traditional understanding of granulation, top spraying can also be used for coating some products. However, this kind of coating, unlike the conventionally understood bottom spray coating, cannot fully achieve functional coating, but plays a certain role. barrier, and cannot achieve precise coating. The most suitable